Recently, the Office of the Shenzhen Municipal Science and Technology Award Committee has announced the proposed awards for all categories of the 2022 Shenzhen Science and Technology Awards. In 2022, our university applied for 58 items of Shenzhen Science and Technology Awards as the first completed unit, all of which were successfully qualified for a competition. In the end, we won 12 awards as the first completed unit, including 2 first prizes, 8 second prizes, 1 youth award, and 1 patent award. In addition, 2 second prizes were awarded to participating units. In both aspects of total prizes and first prizes awarded, it has reached a new altitude in our university’s history, ranking first in the city in the aspect of total prizes awarded.
“Molecular mechanism of genomic stability maintenance” won the first prize in the natural science category.
Genomic DNA is the most important genetic substance. Facing the DNA replication pressure, cell division, exogenous substances (such as radiation, carcinogens, viral infections) and reactive free radicals produced by endogenous metabolism, human genomic DNA experiences tens of trillions of damage events every day. Delayed or incorrect DNA repair makes genomic DNA abnormal and eventually leads to genomic instability. Therefore, accurate and efficient DNA Damage Repair - DDR is the core biological basis for maintaining genomic stability and preventing diseases related to genomic instability (such as tumors), and it is also the core target for treating these diseases.
As one of the core regulatory molecules, ATM plays a crucial role in the DDR process, and its function runs through the whole spatiotemporal regulation of DNA damage recognition, signal transduction and repair completion. It is of great scientific significance to study the regulatory mechanism related to ATM for understanding the maintenance of genomic stability and the diagnosis and treatment of related diseases in the DDR process. Focusing on this major scientific issue, the team conducted a systematic and in-depth mechanism exploration. The new mechanism of spatio-temporal regulation of ATM core molecules throughout the process of DNA damage repair was clarified, the mechanism of genomic instability promoting the occurrence and development of tumors was analyzed, and a series of unresolved key scientific issues in the field was revealed. For example, the initial steps of ATM activation and the key factors of how to accurately inactivate after completing the repair process have achieved significant influence in scientific research achievements in the international field. Relevant research has been published in international first-class journals such asMolecular Cell,PNAS,Science Advances,Nature Comm,Cell Res,Nucleic Acids Res,etc., which has been highly recognized and concerned by internationally renowned experts and widely cited.
“Research on the theory and method of device-free sensing based on ubiquitous RF signals” won the first prize in the natural science category.
Targeting at the challenging and puzzling problems in international academic circles for many years, such as how to achieve the radar of ubiquitous radio frequency signals to make them have good location and behavior sensing capabilities, how to achieve the sensing of objects without any equipment, and how to achieve the integration and optimization of sensing and communication to construct an intelligent medical system, etc., after nearly ten years of research, the team’s main scientific findings were as follows:
For the first time, the feasibility and completeness criteria of device-free location sensing based on ubiquitous RF signals have been systematically proposed and proved. An accurate ranging and location model based on fine-grained physical layer information of wireless signals has been constructed. And a further innovative (device-free) wireless indoor location method without carrying any equipment has been proposed. The dynamic laws between human behavior activities with different granularity and multipath propagation of ubiquitous RF signals have been revealed, and the basic theory and model of device-free behavior activity recognition have been established. The key technologies of human vital signs monitoring and physiological health analysis of the human body based on location and behavior sensing have been proposed. By integrating sensing, communication and big data mining, etc., the intelligent medical technology framework for indoor scenes is constructed, and the leap from apparent physical situational sensing to deep physiological situational mining have been achieved. Related achievements have been awarded the Chinese Patent Excellence Award.
Representative papers have ranked first in the world in aspects of citation frequency among 1,903 papers published in CCFA category and the top international journal “IEEE Transactions on Mobile Computing” in the recent 8 years. The representative papers were selected as the only highlight papers in the current period by the top international journal “IEEE Transactions on Mobile Computing” for reporting. The relevant achievements were reported by Xinhua News Agency and CCTV, and won the Best Paper Award in 4 international conferences. The project has solved important basic scientific issues, played an important role in promoting the development of the discipline, and boosted the computer discipline of Shenzhen University into the top 1‰ of ESI computer discipline in the world. The project also provides important theoretical guidance for economic construction and social development.